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KMID : 0613820090190030390
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Journal of Life Science
2009 Volume.19 No. 3 p.390 ~ p.396
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Biological Activity of Extracts from Cherry Sage (Salvia officinalis L.)
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Cha Woen-Seup
Cho Young-Je
Ju In-Sik
Chun Sung-Sook
Kim Jeung-Hoan
Yun Dong-Hyuck
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Abstract
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In this study, extracts from S. officinalis were tested for antioxidative effects and inhibitory activities against α-amylase, angiotensin converting enzyme (ACE) and xanthine oxidase (XOase). The content of total phenolic compounds in water, 60% ethanol, 60% methanol and 60% acetone extracts were 36.2, 42.7, 40.3 and 39.6 mg/g, respectively. In 60% ethanol extracts, the EDA by DPPH free radical scavenging test of S. officinalis was 66.3±2.2% at 200 μg/ml. The inhibition rate of ABTS was 97.6±0.1%, the antioxidant protection factor was 2.26±0.63 PF, and TBARS was 0.62±0.05 (x100 μM in the control and 0.29±0.02 (x100 μM). Also in 60% ethanol extracts of S. officinalis, the inhibitory activity against XOase was 78% and was not shown to be against ACE. According to the 12.6±0.14 mm of clear zone formed, the inhibition rate against α-Amylase was 7.6% at 200 μg/ml of phenolics content. Antimicrobial activities of 60% ethanol extracts of S. officinalis against Helicobacter pylori exhibited an inhibition rate of 12.5～66.1% according to the 10～15 ㎜ of clear zone at 50～200 μg/ml. The results suggest that the 60% ethanol extracts from Salvia officinalis L. will be useful as natural antioxidants and functional food sources.
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KEYWORD
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Salvia officinalis, xanthine oxidase, angiotensin converting enzyme, Helicobacter pylori, antioxidant activity, antimicrobial activity
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